Let it run for a week and run this
https://raw.githubusercontent.com/major ... qltuner.pl it'll give you some ideas.
max_connections looks a little low for a 16GB I assume you're expecting a lot of traffic for a node that size.
Other useful options are innodb_file_per_table and innodb_buffer_pool_size if possible set innodb_buffer_pool_size to larger than your database size.
_________________
Paid supportHow to ask for help
1. Give details of your problem
2. Post any errors
3. Post relevant logs.
4. Don't hide details i.e. your domain, it just makes things harder
5. Be polite or you'll be eaten by a grue