It depends on what features you're looking for.
- the new Round Cube (
http://roundcube.net) is much better than it was (and better than Squirrel Mail).
- AfterLogic's WebMail Lite (
http://www.afterlogic.org/webmail-lite) is simple but nice (they also have a full featured paid version).
- Zimbra's Open Source Edition (
http://www.zimbra.com/products/zimbra-open-source.html) is very nice, and full featured (they also have a paid version). It is a resource pig and requires a 2GB or 3GB VPS all by itself to run properly.
- Citadel (
http://www.citadel.org) looks like it should be good but I didn't like it. The 'rooms' and 'floors' metaphors would confusing to my clients.
I tried to fight with the old ATMail free version but in the end it wasn't worth the effort. It has security issues and they stopped supporting it a few years back.
MSJ